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The Federal Bridge Law handles relations between the gross weight of the truck, the number of axles, and the spacing between them. This is how they determine is the truck can be on the Interstate Highway system. Each state gets to decide the maximum, under the Federal Bridge Law. They determine by vehicle in combination with axle weight on state and local roads

Signage of business routes varies, depending on the type of route they are derived from. Business routes paralleling U.S. and state highways usually have exactly the same shield shapes and nearly the same overall appearance as the routes they parallel, with a rectangular plate reading "BUSINESS" placed above the shield (either supplementing or replacing the directional plate, depending on the preference of the road agency). In order to better identify and differentiate alternate routes from the routes they parallel, some states such as Maryland are beginning to use green shields for business routes off U.S. highways. In addition, Maryland uses a green shield for business routes off state highways with the word "BUSINESS" in place of "MARYLAND" is used for a state route.

The Federal Bridge Gross Weight Formula is a mathematical formula used in the United States to determine the appropriate gross weight for a long distance moving vehicle, based on the axle number and spacing. Enforced by the Department of Transportation upon long-haul truck drivers, it is used as a means of preventing heavy vehicles from damaging roads and bridges. This is especially in particular to the total weight of a loaded truck, whether being used for commercial moving services or for long distance moving services in general.   According to the Federal Bridge Gross Weight Formula, the total weight of a loaded truck (tractor and trailer, 5-axle rig) cannot exceed 80,000 lbs in the United States. Under ordinary circumstances, long-haul equipment trucks will weight about 15,000 kg (33,069 lbs). This leaves about 20,000 kg (44,092 lbs) of freight capacity. Likewise, a load is limited to the space available in the trailer, normally with dimensions of 48 ft (14.63 m) or 53 ft (16.15 m) long, 2.6 m (102.4 in) wide, 2.7 m (8 ft 10.3 in) high and 13 ft 6 in or 4.11 m high.

Full truckload carriers normally deliver a semi-trailer to a shipper who will fill the trailer with freight for one destination. Once the trailer is filled, the driver returns to the shipper to collect the required paperwork. Upon receiving the paperwork the driver will then leave with the trailer containing freight. Next, the driver will proceed to the consignee and deliver the freight him or herself. At times, a driver will transfer the trailer to another driver who will drive the freight the rest of the way. Full Truckload service (FTL) transit times are generally restricted by the driver's availability. This is according to Hours of Service regulations and distance. It is typically accepted that Full Truckload carriers will transport freight at an average rate of 47 miles per hour. This includes traffic jams, queues at intersections, other factors that influence transit time.  

The feature film "Joy Ride" premiered in 2001, portraying the story of two college-age brothers who by a CB radio while taking a road trip. Although the plot seems lighthearted, it takes a quick turn after one of the brothers attempts a prank on an unknown truck driver. They soon find out the dangerous intentions of this killer driver, who is set on getting his revenge. Seven years later in 2008 the sequel "Joy Ride 2: Dead Ahead" came out on DVD only. Similar to its predecessor, the plot involves another murdering truck driver, a.k.a "Rusty Nail". He essentially plays psychological mind games with a young couple on a road trip.

In 1984 the animated TV series The Transformers told the story of a group of extraterrestrial humanoid robots. However, it just so happens that they disguise themselves as automobiles. Their leader of the Autobots clan, Optimus Prime, is depicted as an awesome semi-truck.

The 1980s were full of happening things, but in 1982 a Southern California truck driver gained short-lived fame. His name was Larry Walters, also known as "Lawn Chair Larry", for pulling a crazy stunt. He ascended to a height of 16,000 feet (4,900 m) by attaching helium balloons to a lawn chair, hence the name. Walters claims he only intended to remain floating near the ground and was shocked when his chair shot up at a rate of 1,000 feet (300 m) per minute. The inspiration for such a stunt Walters claims his poor eyesight for ruining his dreams to become an Air Force pilot.

Some trailers can be towed by an accessible pickup truck or van, which generally need no special permit beyond a regular license. Such examples would be enclosed toy trailers and motorcycle trailers. Specialized trailers like an open-air motorcycle trailer and bicycle trailers are accessible. Some trailers are much more accessible to small automobiles, as are some simple trailers pulled by a drawbar and riding on a single set of axles. Other trailers also have a variety, such as a utility trailer, travel trailers or campers, etc. to allow for varying sizes of tow vehicles.